Description

Fmoc-Gly-Ser[Psi(Me,Me)Pro]-Oh is a specialized, non-hydrolyzable pseudoproline dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for overcoming challenging sequences by reducing aggregation and improving coupling efficiency during the synthesis of complex peptides and peptidomimetics. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, including those targeting metabolic disorders, oncology, and infectious diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the efficient and high-yield synthesis of complex, aggregation-prone peptide sequences.
• Peptidomimetic Drug Discovery: Used to incorporate pseudoproline motifs that enhance the metabolic stability, bioavailability, and conformational rigidity of therapeutic peptide candidates.
• Pharmaceutical R&D: Critical for the research and development of novel peptide-based therapeutics in areas such as oncology, endocrinology, and immunology.
• Bioconjugation and Chemical Biology: Serves as a precursor for creating labeled or modified peptides used in probe development and structure-activity relationship (SAR) studies.
• Academic Research: Employed in university and institutional labs for studying protein folding, peptide structure, and developing new synthetic methodologies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations that require high-purity, specialized amino acid derivatives for client projects.

Basic Information

Product Name	Fmoc-Gly-Ser[Psi(Me,Me)Pro]-Oh
CAS No.	1095952-22-9
Molecular Formula	C₂₆H₂₉N₃O₇
Molecular Weight	495.52 g/mol
Synonyms	Fmoc-Gly-Ser(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycyl-O-(1-methylethyl)-N-(1-methylethyl)serinylproline; Fmoc-Gly-Ser(ψMe,Mepro)-OH; Pseudoproline Dipeptide Derivative; Fmoc-Gly-Ser(tBu)-ψ(Me,Mepro)-OH; Fmoc-Gly-Ser(ψ(Me,Me)Pro)-OH; Fmoc-Gly-Ser[ψ(Me,Me)Pro]-OH; Fmoc-Gly-Ser(ψ(Me,Me)Pro)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Ser[Psi(Me,Me)Pro]-Oh is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive pharmaceutical research. Each batch is analyzed using advanced techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere (e.g., nitrogen or argon) when being weighed out for use. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.