Description

1H-Pyrazolo[3,4-D]Pyrimidine-4-Carboxylic Acid is a high-purity heterocyclic building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the creation of novel, biologically active molecules. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of targeted therapeutics.

Application

This advanced pharmaceutical intermediate is utilized in a variety of specialized research and manufacturing contexts:

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for Active Pharmaceutical Ingredient (API) manufacturing.
• Biochemical Tool Compound Development: Serves as a core scaffold for creating probes and inhibitors used in biological target validation and assay development.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.

Basic Information

Product Name	1H-Pyrazolo[3,4-D]Pyrimidine-4-Carboxylic Acid
CAS No.	1095822-28-8
Molecular Formula	C6H4N4O2
Molecular Weight	164.12 g/mol
Synonyms	4-Pyrazolo[3,4-d]pyrimidinecarboxylic acid; 1H-Pyrazolo[3,4-d]pyrimidine-4-carboxylic acid; PPAC; Pyrazolopyrimidine-4-carboxylic acid; 4-Carboxy-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo(3,4-d)pyrimidine-4-carboxylic acid; 1095822-28-8
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrazolo[3,4-D]Pyrimidine-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored away from strong light sources. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.