Description

Fmoc-Arg(Z)2-Oh CAS NO 1094617-45-4 is a protected arginine derivative, specifically an Nα-Fmoc, Nω,Nω'-bis(benzyloxycarbonyl)-L-arginine, which is a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in enabling the controlled and efficient assembly of complex peptides and proteins, particularly those containing the essential amino acid arginine, by providing orthogonal protection for the guanidino group. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic reagents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, facilitating the incorporation of arginine residues into peptide chains.
• Pharmaceutical Research: Used in the research and development of novel peptide-based therapeutics, including hormones, antimicrobial peptides, and enzyme inhibitors.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide conjugates used in biochemical assays and diagnostic imaging.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Institutional Research: Essential for fundamental studies in biochemistry, molecular biology, and medicinal chemistry involving peptide structure and function.
• Custom Peptide Service Providers: A fundamental raw material for companies offering bespoke peptide synthesis services to the research community.

Basic Information

Product Name	Fmoc-Arg(Z)2-Oh
CAS No.	1094617-45-4
Molecular Formula	C₃₇H₃₇N₅O₈
Molecular Weight	679.72 g/mol
Synonyms	Nα-Fmoc-Nω,Nω'-bis(benzyloxycarbonyl)-L-arginine; Fmoc-Arg(Boc)2-OH (common misnomer, correct protecting group is Z); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nω,Nω'-bis[(benzyloxy)carbonyl]-L-arginine; Fmoc-L-Arg(Z)2-OH; Fmoc-Arg(Z,Z)-OH; Fmoc-Arg(Bzl)2-OH; Nα-(9-Fluorenylmethyloxycarbonyl)-Nω,Nω'-bis(benzyloxycarbonyl)arginine; Protected L-Arginine Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Z)2-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.