Description

2-Chloro-n-Ethyl-5-Iodopyrimidin-4-Amine is a high-value halogenated pyrimidine derivative, serving as a critical building block in modern synthetic organic chemistry. Its molecular structure, featuring chloro, iodo, and amine substituents, makes it an essential intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors and antiviral agents.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and pesticides by acting as a core heterocyclic scaffold.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Material Science: Employed in the research of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient pyrimidine core.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide distinct sites for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification.
• Nucleic Acid Chemistry: Potential use as a modified base analog in oligonucleotide synthesis for therapeutic and diagnostic applications.

Basic Information

Product Name	2-Chloro-n-Ethyl-5-Iodopyrimidin-4-Amine
CAS No.	1093847-73-4
Molecular Formula	C6H7ClIN3
Molecular Weight	283.50 g/mol
Synonyms	4-Amino-2-chloro-5-iodo-N-ethylpyrimidine; 2-Chloro-5-iodo-N-ethylpyrimidin-4-amine; 2-Chloro-5-iodo-4-(ethylamino)pyrimidine; 5-Iodo-2-chloro-N-ethyl-4-pyrimidinamine; 1093847-73-4; 4-Pyrimidinamine, 2-chloro-5-iodo-N-ethyl-
EINECS	Contact for details

Quality Control

Our 2-Chloro-n-Ethyl-5-Iodopyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.