Description

(2S,4R)-1-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-4-Phenylpyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a chiral pyrrolidine scaffold protected by a fluorenylmethoxycarbonyl (Fmoc) group. This compound matters as a critical chiral building block and intermediate in modern pharmaceutical research, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, protease inhibitors, and other bioactive compounds where the (2S,4R) stereochemistry is essential for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and cardiovascular diseases.
• Peptide Synthesis: Serves as a protected, stereochemically-defined amino acid component in solid-phase and solution-phase peptide synthesis (SPPS).
• Protease Inhibitor Development: Used in constructing the core structures of inhibitors targeting specific enzymes like dipeptidyl peptidase-4 (DPP-4).
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material for the asymmetric synthesis of more complex, biologically active molecules.
• Reference Standard: Used as an analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	(2S,4R)-1-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)-4-Phenylpyrrolidine-2-Carboxylic Acid
CAS No.	1093651-96-7
Molecular Formula	C26H23NO4
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-(2S,4R)-4-phenylproline; (2S,4R)-Fmoc-4-phenylproline; (2S,4R)-1-Fmoc-4-phenylpyrrolidine-2-carboxylic acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-phenyl-L-proline; Fmoc-cis-4-phenylproline; Fmoc-4-Ph-Pro-OH; (2S,4R)-1-[(9-Fluorenylmethoxycarbonyl)]-4-phenyl-2-pyrrolidinecarboxylic acid; (2S,4R)-4-Phenyl-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP guidelines for the production of materials intended for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.