Description

Ethyl 4-(2-Bromo-4-Fluorophenyl)-6-Methyl-2-(Thiazol-2-Yl)-1,4-Dihydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the dihydropyrimidine class. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), valued for its precise molecular architecture that enables targeted drug development. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the discovery and production of new therapeutic agents, particularly in areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those targeting specific enzymatic pathways.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• API Synthesis: Serves as a core scaffold for constructing complex molecules with potential biological activity in therapeutic areas such as oncology or neurology.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing route of target molecules.
• Academic Research: Used in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and novel synthetic methodologies.

Basic Information

Product Name	Ethyl 4-(2-Bromo-4-Fluorophenyl)-6-Methyl-2-(Thiazol-2-Yl)-1,4-Dihydropyrimidine-5-Carboxylate
CAS No.	1092952-98-1
Molecular Formula	C₁₇H₁₅BrFN₃O₂S
Molecular Weight	424.29 g/mol
Synonyms	4-(2-Bromo-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester; Ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate; 1,4-Dihydropyrimidine-5-carboxylic acid, 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(2-thiazolyl)-, ethyl ester; 1092952-98-1; DHPM-thiazole derivative; Bromo-fluoro dihydropyrimidine-thiazole intermediate.
EINECS	Contact for details

Quality Control

Our Ethyl 4-(2-Bromo-4-Fluorophenyl)-6-Methyl-2-(Thiazol-2-Yl)-1,4-Dihydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.