Description

(Betar)-β-Cyclopentyl-4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile (2Z)-2-Butenedioate is a high-purity, non-racemic chemical building block and advanced pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly for its role as a precursor in kinase inhibitor synthesis. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel kinase inhibitors and other targeted small-molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for oncology and inflammatory disease targets.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Potential use as a reference standard or probe compound in enzymatic assays and biochemical screening.
• Custom Synthesis: Employed by fine chemical suppliers for the custom manufacturing of complex, high-value molecules for client-specific projects.

Basic Information

Product Name	(Betar)-β-Cyclopentyl-4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile (2Z)-2-Butenedioate
CAS No.	1092939-15-5
Molecular Formula	C₂₁H₂₃N₇O₄
Molecular Weight	437.46 g/mol
Synonyms	(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile (2Z)-2-butenedioate; (R)-β-Cyclopentyl-4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile Fumarate; (R)-Enantiomer of β-Cyclopentyl-4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile Fumarate; 1H-Pyrazole-1-propanenitrile, 4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-β-cyclopentyl-, (βR)-, (2Z)-2-butenedioate; Fumarate salt of (R)-β-Cyclopentyl-4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile; CAS 1092939-15-5
EINECS	Contact for details

Quality Control

Our (Betar)-β-Cyclopentyl-4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile (2Z)-2-Butenedioate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.