Description

1-[4-(Difluoromethyl)-6-(1,3-Dimethyl-1H-Pyrazol-4-Yl)Pyrimidin-2-Yl]Proline is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a sophisticated building block with a proline moiety and a difluoromethylpyrimidine core. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing novel therapeutics, particularly in areas requiring targeted molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, particularly for small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved efficacy and pharmacokinetic profiles.
• API Synthesis: Integral in the production route for active pharmaceutical ingredients targeting specific disease pathways.
• Preclinical Development: Supplies material for the synthesis of compounds required for in vitro and in vivo biological testing and toxicology studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.
• Protease Inhibitor Research: The proline component suggests potential application in the development of inhibitors for proteolytic enzymes.

Basic Information

Product Name	1-[4-(Difluoromethyl)-6-(1,3-Dimethyl-1H-Pyrazol-4-Yl)Pyrimidin-2-Yl]Proline
CAS No.	1092840-98-6
Molecular Formula	C15H17F2N5O2
Molecular Weight	337.33 g/mol
Synonyms	L-Proline, 1-[4-(difluoromethyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)-2-pyrimidinyl]-; (S)-1-(4-(Difluoromethyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)pyrimidin-2-yl)pyrrolidine-2-carboxylic acid; 1092840-98-6; Proline derivative with difluoromethylpyrimidine; 1-(4-(Difluoromethyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)pyrimidin-2-yl)-L-proline; 2-Pyrimidineproline derivative; DFMP-Proline intermediate
EINECS	Contact for details

Quality Control

Our 1-[4-(Difluoromethyl)-6-(1,3-Dimethyl-1H-Pyrazol-4-Yl)Pyrimidin-2-Yl]Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support audits and regulatory documentation for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.