Description

1-Cyclopentyl-3-(1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted therapies. This compound is a key synthetic building block valued for its role in the discovery and development of novel kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel small-molecule kinase inhibitors for therapeutic applications.
• Oncology Research: Used in the development of targeted cancer therapies, particularly those aimed at specific protein kinases involved in cell proliferation and survival.
• Biochemical Assay Development: Serves as a reference standard or active compound in high-throughput screening (HTS) and enzymatic assays to identify and characterize new drug candidates.
• Structure-Activity Relationship (SAR) Studies: Employed by medicinal chemists to explore and optimize the biological activity of pyrazolo[3,4-d]pyrimidine-based compounds.
• Preclinical Development: Used in the synthesis of candidate compounds for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	1-Cyclopentyl-3-(1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine
CAS No.	1092788-83-4
Molecular Formula	C19H19N7
Molecular Weight	345.40 g/mol
Synonyms	1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-; 1092788-83-4; Crizotinib Intermediate; Crizotinib Related Compound; PF-02341066 Intermediate; Kinase Inhibitor Intermediate; ALK Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 1-Cyclopentyl-3-(1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.