Description

n-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-Yl)-n-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound is a key synthetic building block for the development of targeted kinase inhibitors and other small molecule therapeutics. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of investigational kinase inhibitors for oncology and immunology.
• Drug Discovery Research: Serves as a core scaffold for medicinal chemistry programs aiming to develop novel therapeutic agents.
• Biochemical Tool Compound: Used in vitro to study enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of complex, high-value organic molecules.
• Reference Standard: Provides a certified material for analytical method development and quality control in API production.

Basic Information

Product Name	n-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-Yl)-n-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine
CAS No.	1092578-45-4
Molecular Formula	C21H27N5
Molecular Weight	349.48 g/mol
Synonyms	1-Benzyl-4-methyl-3-[(methylamino)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)methyl]piperidine; (3R,4S)-1-Benzyl-4-methyl-N-methyl-1,2,3,4-tetrahydropyridin-3-amine fused with pyrrolopyrimidine; 4-[[(3R,4S)-1-Benzyl-4-methyl-3-piperidinyl]methylamino]-7H-pyrrolo[2,3-d]pyrimidine; Kinase Inhibitor Intermediate 1092578-45-4; BMS-936420 Intermediate (related compound); Pyrrolopyrimidine-piperidine hybrid; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-((3R,4S)-1-Benzyl-4-Methylpiperidin-3-Yl)-n-Methyl-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm stereochemistry, and comprehensive identification tests. Certificates of Analysis (COA) detailing purity, residual solvents, and other critical parameters are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.