Description

3-Ethoxy-2,6-Difluorophenol, Jrd, 97% is a high-purity fluorinated phenolic ether building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine and alkoxy groups is crucial for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluorophenol moiety enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Employed to introduce fluorine and phenolic functionality into polymer backbones, enhancing thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and constructing fluorine-containing molecular libraries for screening.

Basic Information

Product Name	3-Ethoxy-2,6-Difluorophenol, Jrd, 97%
CAS No.	1092461-31-8
Molecular Formula	C8H8F2O2
Molecular Weight	174.15 g/mol
Synonyms	2,6-Difluoro-3-ethoxyphenol; 3-Ethoxy-2,6-difluorophenol; Phenol, 3-ethoxy-2,6-difluoro-; JRD (proprietary grade identifier); 2,6-Difluoro-3-hydroxyethoxybenzene (tautomeric form); Fluorinated phenolic ether; Difluorinated alkoxyphenol
EINECS	Contact for details

Quality Control

Our 3-Ethoxy-2,6-Difluorophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We are committed to meeting the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.