Description

5-Fluoro-2-Trifluoromethoxybenzaldehyde is a high-purity fluorinated aromatic aldehyde building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethoxy and fluorine substituents impart desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to develop advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Chemical Research & Development: A versatile reagent for academic and industrial research in organofluorine chemistry and novel synthetic methodology development.

Basic Information

Product Name	5-Fluoro-2-Trifluoromethoxybenzaldehyde
CAS No.	1092460-81-5
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2-Trifluoromethoxy-5-fluorobenzaldehyde; 5-Fluoro-2-(trifluoromethoxy)benzaldehyde; Benzaldehyde, 5-fluoro-2-(trifluoromethoxy)-; 5-Fluoro-α,α,α-trifluoro-o-anisaldehyde
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Trifluoromethoxybenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.