Description

1-(5-Bromo-3-Fluoro-2-Hydroxyphenyl)Ethanone is a high-purity, halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a phenolic hydroxyl group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced herbicides, fungicides, and pesticides, where the bromo and fluoro substituents can enhance biological activity and environmental stability.
• Material Science Precursor: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials, where its halogenated aromatic core contributes to desired material properties.
• Chemical Research: Employed in academic and industrial R&D labs for method development, such as cross-coupling reactions (Suzuki, Buchwald-Hartwig) and selective functional group transformations.
• Fluorescent Dye & Sensor Development: Acts as a starting material for synthesizing complex fluorophores and molecular sensors due to its modifiable phenolic and ketone functionalities.

Basic Information

Product Name	1-(5-Bromo-3-Fluoro-2-Hydroxyphenyl)Ethanone
CAS No.	1089706-28-4
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	5'-Bromo-3'-fluoro-2'-hydroxyacetophenone; 1-Acetyl-5-bromo-3-fluoro-2-hydroxybenzene; 2-Acetyl-4-bromo-6-fluorophenol; 5-Bromo-3-fluoro-2-hydroxyacetophenone; 2-Hydroxy-5-bromo-3-fluoroacetophenone; (5-Bromo-3-fluoro-2-hydroxyphenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Bromo-3-Fluoro-2-Hydroxyphenyl)Ethanone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles by HPLC, GC, and NMR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.