Description

5-(2-(2-Chloropyrimidin-4-Yl)Acetyl)-n-(2,6-Difluorophenyl)-2-Methoxybenzamide is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex heterocyclic compounds for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and other therapeutic areas.
• Organic Synthesis Building Block: Used in research-scale and process chemistry for constructing complex molecular architectures containing pyrimidine and benzamide motifs.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the discovery of new biologically active molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and APIs.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-(2-(2-Chloropyrimidin-4-Yl)Acetyl)-n-(2,6-Difluorophenyl)-2-Methoxybenzamide
CAS No.	1089278-52-3
Molecular Formula	C20H14ClF2N3O3
Molecular Weight	417.80 g/mol
Synonyms	5-[2-(2-Chloropyrimidin-4-yl)acetyl]-N-(2,6-difluorophenyl)-2-methoxybenzamide; 5-(2-(2-Chloropyrimidin-4-yl)acetyl)-N-(2,6-difluorophenyl)-2-methoxybenzamide; 1089278-52-3; N-(2,6-Difluorophenyl)-5-[2-(2-chloropyrimidin-4-yl)acetyl]-2-methoxybenzamide; 2-Methoxy-5-[2-(2-chloropyrimidin-4-yl)acetyl]-N-(2,6-difluorophenyl)benzamide; Benzamide, N-(2,6-difluorophenyl)-5-[2-(2-chloropyrimidin-4-yl)acetyl]-2-methoxy-
EINECS	Contact for details

Quality Control

Our 5-(2-(2-Chloropyrimidin-4-Yl)Acetyl)-n-(2,6-Difluorophenyl)-2-Methoxybenzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if opened for prolonged periods.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.