Description

4-Bromo-2-Cyclopropylpyrimidine is a high-purity halogenated pyrimidine derivative, a crucial building block in modern organic synthesis. Its core value lies in enabling the rapid construction of complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery and material science applications.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new fungicides, herbicides, and plant growth regulators.
• Material Science: Serves as a precursor for functionalized ligands and monomers in advanced polymers and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Medicinal Chemistry Library Synthesis: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Chemical Biology Probes: Used to create tagged or modified molecules for studying biological pathways and target engagement.

Basic Information

Item	Details
Product Name	4-Bromo-2-Cyclopropylpyrimidine
CAS No.	1086381-83-0
Molecular Formula	C7H7BrN2
Molecular Weight	199.05 g/mol
Synonyms	2-Cyclopropyl-4-bromopyrimidine; 4-Bromo-2-cyclopropyl-pyrimidine; Pyrimidine, 4-bromo-2-cyclopropyl-; 1086381-83-0; 4-Bromo-2-cyclopropylpyrimidine; 4-Bromo-2-cyclopropyl pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Cyclopropylpyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.