Description

{1-[4-(Trifluoromethyl)Phenyl]Cyclobutyl}Methylamine is a high-value, synthetically versatile amine building block featuring a cyclobutyl core and a trifluoromethylphenyl substituent. This compound matters for its unique structural motif, which combines the conformational constraint of the cyclobutane ring with the electronic and lipophilic properties imparted by the trifluoromethyl group, making it a critical intermediate in advanced organic synthesis. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scale-up of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Acts as a monomer or functionalization agent for advanced polymers with specific thermal or optical properties.
• Chemical Biology Probe Synthesis: Utilized to build molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D programs.

Basic Information

Product Name	{1-[4-(Trifluoromethyl)Phenyl]Cyclobutyl}Methylamine
CAS No.	1086379-25-0
Molecular Formula	C12H14F3N
Molecular Weight	229.24 g/mol
Synonyms	[1-[4-(Trifluoromethyl)phenyl]cyclobutyl]methanamine; 1-[[4-(Trifluoromethyl)phenyl]cyclobutyl]methylamine; (1-(4-(Trifluoromethyl)phenyl)cyclobutyl)methanamine; 1-(4-(Trifluoromethyl)phenyl)cyclobutanemethylamine; (1-(4-Trifluoromethylphenyl)cyclobutyl)methylamine; α-Methyl-4-(trifluoromethyl)cyclobutanemethylamine; 4-(Trifluoromethyl)-α-methylcyclobutanemethylamine
EINECS	Contact for details

Quality Control

Our {1-[4-(Trifluoromethyl)Phenyl]Cyclobutyl}Methylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.