Description

5-Trifluoromethoxy-1H-Indazole-3-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core functionalized with a trifluoromethoxy group and an aldehyde. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, neurology, and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, leveraging the trifluoromethoxy group for improved biological activity and environmental persistence.
• Chemical Biology Probe: Serves as a versatile scaffold for creating molecular probes to study enzyme function and biological pathways due to its reactive aldehyde group.
• Material Science Precursor: Potential use in the development of specialty polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up activities.

Basic Information

Product Name	5-Trifluoromethoxy-1H-Indazole-3-Carbaldehyde
CAS No.	1082040-40-1
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.14 g/mol
Synonyms	5-(Trifluoromethoxy)-1H-indazole-3-carboxaldehyde; 1H-Indazole-3-carboxaldehyde, 5-(trifluoromethoxy)-; 5-Trifluoromethoxyindazole-3-carbaldehyde; 3-Formyl-5-trifluoromethoxyindazole; 5-Trifluoromethoxy-1H-indazole-3-carboxaldehyde; 5-Trifluoromethoxy-1H-indazole-3-aldehyde; 1082040-40-1; 5-TFMO-indazole-3-CHO
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethoxy-1H-Indazole-3-Carbaldehyde is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.