Description

H-Tyr(Propargyl)-Oh is a non-natural, propargyl-modified tyrosine derivative, a crucial building block in advanced organic synthesis and peptide chemistry. Its primary value lies in the alkyne (propargyl) functional group, which enables highly specific, bioorthogonal click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in pharmaceutical R&D, proteomics, and bioconjugation, where it is used to create labeled peptides, develop novel drug conjugates, and engineer functional biomaterials.

Application

• Peptide-Based Drug Discovery: Incorporation into peptide sequences to introduce clickable handles for attaching payloads like fluorophores, toxins, or polyethylene glycol (PEG) chains.
• Bioconjugation & Probe Development: Serving as a key reagent for site-specific labeling of proteins, antibodies, and other biomolecules via click chemistry for imaging, diagnostics, and targeted therapies.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) and the synthesis of activity-based probes to study enzyme function and interactions.
• Material Science: Functionalization of polymer backbones and surfaces to create smart biomaterials with tailored biological activity.
• Library Synthesis: A valuable building block for generating diverse chemical libraries in high-throughput screening for drug lead identification.

Basic Information

Product Name	H-Tyr(Propargyl)-Oh
CAS No.	1080496-42-9
Molecular Formula	C₁₂H₁₃NO₃
Molecular Weight	219.24 g/mol
Synonyms	L-Tyrosine, O-propargyl-; O-Propargyl-L-tyrosine; (S)-2-Amino-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoic acid; Fmoc-Tyr(Propagyl)-OH (protected form); H-Tyr(Propagyl)-OH; Clickable Tyrosine; Propargyloxy-L-phenylalanine; Tyrosine Propargyl Ether
EINECS	Contact for details

Quality Control

Our H-Tyr(Propargyl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.