Description

Ethyl 4-Chloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrimidine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially kinase inhibitors.
• Oncology Research: Serves as a core scaffold for constructing molecules targeting specific cancer pathways.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Chemical Synthesis: Employed in multi-step organic syntheses to introduce the dihydropyridopyrimidine moiety.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for exploring new heterocyclic chemistry and bioactivity.

Basic Information

Product Name	Ethyl 4-Chloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate
CAS No.	1078103-66-8
Molecular Formula	C₁₀H₁₀ClN₃O₂
Molecular Weight	239.66 g/mol
Synonyms	4-Chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylic acid ethyl ester; Ethyl 4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate; 6(5H)-Carboxylic acid, 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-, ethyl ester; 4-Chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Chloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.