Description

2,4-Bis-(Benzyloxy)-5-(5,5-Dimethyl-[1,3,2]-Dioxaborinan-2-Yl)Pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for oncology and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially nucleotide analogs and kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic ester moiety facilitates the formation of carbon-carbon bonds under mild conditions, essential for constructing biaryl structures in drug molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a reliable and stable intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Chemical Biology Probes: Can be incorporated into molecules designed to study biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of novel crop protection agents with complex heterocyclic structures.

Basic Information

Item	Details
Product Name	2,4-Bis-(Benzyloxy)-5-(5,5-Dimethyl-[1,3,2]-Dioxaborinan-2-Yl)Pyrimidine
CAS No.	1072944-91-2
Molecular Formula	C24H27BN2O4
Molecular Weight	418.30 g/mol
Synonyms	5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-2,4-bis(phenylmethoxy)pyrimidine; 2,4-Bis(benzyloxy)-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyrimidine; 2,4-Di-O-benzyl-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyrimidine; 2,4-Bis-O-benzyl-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyrimidine; 2,4-Bis(benzyloxy)pyrimidine-5-boronic acid, pinacol ester; 2,4-Bis(benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine analog; BBN-Pyrimidine intermediate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 2,4-Bis-(Benzyloxy)-5-(5,5-Dimethyl-[1,3,2]-Dioxaborinan-2-Yl)Pyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.