Description

2-Hydroxy-4-(Trifluoromethoxy)Benzaldehyde is a versatile aromatic aldehyde building block featuring both a phenolic hydroxyl group and a trifluoromethoxy substituent. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced lipophilicity, metabolic stability, and electronic properties are required. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) agents, anti-inflammatory compounds, and kinase inhibitors, where the trifluoromethoxy group improves bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy moiety to enhance pesticidal activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science: Building block for advanced polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties and intermolecular interactions.
• Chemical Research: Essential reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethoxy)Benzaldehyde
CAS No.	1071156-25-6
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	4-(Trifluoromethoxy)salicylaldehyde; 2-Hydroxy-4-(trifluoromethoxy)benzaldehyde; Salicylaldehyde, 4-(trifluoromethoxy)-; 4-Trifluoromethoxysalicylaldehyde; 2-Formyl-5-(trifluoromethoxy)phenol; 5-(Trifluoromethoxy)-2-hydroxybenzaldehyde; Benzaldehyde, 2-hydroxy-4-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets exacting standards for research and production. Certificates of Analysis (COA) with complete batch-specific data are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.