Description

n- Fmoc-N’-Methyl-L-Asparagine is a protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound matters for its role in introducing the unique N-methylated asparagine residue into peptide chains, a modification known to enhance metabolic stability and alter biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of N-methyl-L-asparagine into custom peptide sequences.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, where N-methylation improves pharmacokinetic properties.
• Peptidomimetic Design: Essential for creating modified peptide analogs with enhanced stability against enzymatic degradation.
• Combinatorial Chemistry Libraries: Serves as a specialized monomer for generating diverse peptide libraries for high-throughput screening.
• Bioconjugation: The Fmoc protecting group allows for selective deprotection, enabling further chemical modification of the peptide backbone.
• Academic Research: Employed in biochemical and structural studies to investigate the effects of side-chain methylation on protein folding and function.

Basic Information

Product Name	n- Fmoc-N’-Methyl-L-Asparagine
CAS No.	1070874-06-4
Molecular Formula	C₂₁H₂₂N₂O₆
Molecular Weight	398.41 g/mol
Synonyms	Fmoc-N-Me-Asn-OH; Fmoc-N-methyl-L-asparagine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-methyl-L-asparagine; (2S)-4-amino-2-[[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino]-4-oxobutanoic acid; N-Fmoc-N'-methyl-L-asparagine; N-α-Fmoc-N'-methyl-L-asparagine; Fmoc-Asn(NMe)-OH; FMOC-N-METHYL-ASPARAGINE
EINECS	Contact for details

Quality Control

Our n- Fmoc-N’-Methyl-L-Asparagine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and residual solvent content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.