Description

4-[6-Chloro-2-(4-Cyano-Phenylamino)-Pyrimidin-4-Yloxy]-3,5-Dimethyl-Benzonitrile is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor development. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted therapeutic agents, especially kinase inhibitors for oncology and inflammatory diseases.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling the exploration of new structure-activity relationships (SAR) in drug discovery.
• Academic Research: Used in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and the development of novel synthetic methodologies.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for potential drug candidates during pre-clinical and early development phases.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	4-[6-Chloro-2-(4-Cyano-Phenylamino)-Pyrimidin-4-Yloxy]-3,5-Dimethyl-Benzonitrile
CAS No.	1070377-34-2
Molecular Formula	C20H14ClN5O
Molecular Weight	375.81 g/mol
Synonyms	4-[6-Chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile; 4-((6-Chloro-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile; CAS 1070377-34-2; 4-[6-Chloro-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile; 3,5-Dimethyl-4-{[6-chloro-2-(4-cyanophenylamino)pyrimidin-4-yl]oxy}benzonitrile
EINECS	Contact for details

Quality Control

Our production of 4-[6-Chloro-2-(4-Cyano-Phenylamino)-Pyrimidin-4-Yloxy]-3,5-Dimethyl-Benzonitrile adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.