Description

2-Fluoro-4-Bromo-5-Aminotoluene is a high-purity halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides a versatile scaffold for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine substituents enhance biological activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Serves as an intermediate for producing complex azo dyes and high-performance pigments with improved lightfastness and color properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Buchwald-Hartwig aminations, enabling rapid library synthesis.
• Chemical Biology & Proteomics: Utilized as a reagent for labeling and modifying biomolecules, facilitating studies in drug discovery and diagnostic assay development.

Basic Information

Product Name	2-Fluoro-4-Bromo-5-Aminotoluene
CAS No.	1065076-39-2
Molecular Formula	C7H7BrFN
Molecular Weight	204.04 g/mol
Synonyms	5-Amino-2-fluoro-4-bromotoluene; 4-Bromo-2-fluoro-5-methylaniline; 2-Fluoro-4-bromo-5-methylaniline; 5-Methyl-2-fluoro-4-bromoaniline; Toluene, 2-fluoro-4-bromo-5-amino-; 2-Fluoro-4-bromo-5-methylbenzenamine; 1-Bromo-2-fluoro-4-amino-5-methylbenzene; 4-Bromo-2-fluoro-5-aminotoluene
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Bromo-5-Aminotoluene is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing comprehensive specifications. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to light and oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.