Description

2-Chloro-9-Cyclopentyl-7,7-Difluoro-5,8-Dihydropyrimido[4,5-B][1,4]Diazepin-6-One is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound matters for its role as a critical building block in modern medicinal chemistry, enabling the development of targeted therapies. It is primarily needed by research institutions and pharmaceutical manufacturers focused on oncology, neurology, and other therapeutic areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Process Development & Scale-Up: Serves as a critical raw material for process chemistry teams during route scouting and GMP manufacturing preparation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.
• Academic Research: Utilized in university and institutional labs for exploring new chemical entities and biological mechanisms.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biochemical and cellular assays due to its functionalized core structure.

Basic Information

Product Name	2-Chloro-9-Cyclopentyl-7,7-Difluoro-5,8-Dihydropyrimido[4,5-B][1,4]Diazepin-6-One
CAS No.	1062246-01-8
Molecular Formula	C15H15ClF2N4O
Molecular Weight	340.76 g/mol
Synonyms	2-Chloro-9-cyclopentyl-7,7-difluoro-5,8-dihydropyrimido[4,5-b][1,4]diazepin-6(7H)-one; 1062246-01-8; 2-Chloro-9-cyclopentyl-7,7-difluoro-5,8-dihydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one; Pyrimido[4,5-b][1,4]diazepin-6-one, 2-chloro-9-cyclopentyl-7,7-difluoro-5,8-dihydro-; 9-Cyclopentyl-2-chloro-7,7-difluoro-5,8-dihydropyrimido[4,5-b][1,4]diazepin-6-one
EINECS	Contact for details

Quality Control

Our 2-Chloro-9-Cyclopentyl-7,7-Difluoro-5,8-Dihydropyrimido[4,5-B][1,4]Diazepin-6-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.