Description

(Dab7)-Leiurotoxin I is a synthetic, site-specifically modified analog of the scorpion-derived potassium channel blocker, Leiurotoxin I. This engineered peptide is of significant value for advanced biochemical and pharmacological research, particularly in the study of ion channel structure, function, and modulation. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, cardiovascular research, and drug discovery targeting potassium channels.

Application

• Neuroscience Research: As a high-affinity, selective tool for probing the structure and function of calcium-activated potassium (SK) channels.
• Drug Discovery & Development: Serving as a reference standard and molecular scaffold for designing novel therapeutics targeting ion channelopathies.
• Biochemical Assays: Used in competitive binding studies, patch-clamp electrophysiology, and other in vitro assays to characterize channel inhibitors.
• Structural Biology: Aiding in X-ray crystallography and NMR studies to elucidate toxin-channel interaction sites and mechanisms.
• Safety Pharmacology: Employed in preclinical studies to assess potential off-target cardiac and neurological effects of new chemical entities.

Basic Information

Product Name	(Dab7)-Leiurotoxin I
CAS No.	1061556-49-7
Molecular Formula	C165H265N55O48S6
Molecular Weight	~3810.5 g/mol
Synonyms	Dab7-Leiurotoxin I; Leiurotoxin I (Dab7); scyllatoxin analog; scyllatoxin (Dab7); Kaliotoxin-1 analog; Charybdotoxin homolog; Peptide toxin inhibitor; Potassium channel blocker peptide; SK channel inhibitor
EINECS	Contact for details

Quality Control

Our (Dab7)-Leiurotoxin I is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization, including mass spectrometry for sequence confirmation and purity assessment by multiple orthogonal methods. Certificates of Analysis (COA) detailing purity, identity, and content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.