Description

4-Amino-6-Cyano-3(2H)-Quinazolinecarboxylic Acid-1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex, biologically active molecules, particularly within medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted anticancer agents and kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Organic Synthesis Building Block: Employed in the construction of complex quinazoline and fused heterocyclic scaffolds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	4-Amino-6-Cyano-3(2H)-Quinazolinecarboxylic Acid-1,1-Dimethylethyl Ester
CAS No.	1060795-16-5
Molecular Formula	C14H14N4O2
Molecular Weight	270.29 g/mol
Synonyms	tert-Butyl 4-amino-6-cyano-3-oxo-3,4-dihydroquinazoline-2-carboxylate; 4-Amino-6-cyano-2H-quinazoline-3-carboxylic acid 1,1-dimethylethyl ester; 4-Amino-6-cyano-3(2H)-quinazolinone-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-4-amino-6-cyano-3(2H)-quinazolinone; BOC-protected 4-amino-6-cyanoquinazolinone; 4-Amino-6-cyano-3-oxo-3,4-dihydroquinazoline-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 4-Amino-6-Cyano-3(2H)-Quinazolinecarboxylic Acid-1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.