Description

Fmoc-Arg(Pyrrodine, Pbf)-Oh CAS NO 1060769-57-4 is a specialized, orthogonally protected arginine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides critical side-chain protection, preventing unwanted side reactions and enabling the efficient construction of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and fine chemical synthesis who require high-purity, reliable building blocks for developing therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid building block for the Fmoc/t-Bu strategy.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including those targeting GPCRs, enzymes, and protein-protein interactions.
• Bioconjugation: Creating labeled peptides for diagnostic imaging or targeted drug delivery systems.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive molecules.
• Peptidomimetic Development: Incorporation into non-natural peptide structures to enhance metabolic stability and bioavailability.
• Academic & Industrial R&D: Fundamental research in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	Fmoc-Arg(Pyrrodine, Pbf)-Oh
CAS No.	1060769-57-4
Molecular Formula	C33H45N5O7S
Molecular Weight	655.81 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-L-arginine(Pbf)-OH; Fmoc-Arg(Pbf)-OH, 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl protection; N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(Pbf)-L-arginine; Fmoc-Arg(Pbf); Fmoc-Arg(Pyrrodine,Pbf)-OH; Fmoc-Arg(Pyrrodine, Pbf)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(Pyrrodine, Pbf)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with research and cGMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.