Description

(S)-Fmoc-2-Amino-5-[(N'-Pbf-N''-Boc-Amino)-Guanidino]-Pentanoic Acid is a sophisticated, orthogonally protected arginine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and high-fidelity incorporation of arginine residues, particularly in the synthesis of complex peptides and peptidomimetics. It is an essential building block for pharmaceutical researchers and manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated synthesis of peptide chains containing arginine.
• Pharmaceutical R&D: Building block for the discovery and development of novel peptide-based therapeutics, including hormones, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Used in the creation of modified peptide structures with enhanced stability, bioavailability, or receptor specificity.
• Bioconjugation: Facilitates the site-specific labeling or functionalization of peptides and proteins via the reactive guanidino group after selective deprotection.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to identify new bioactive compounds.
• Academic Research: Essential reagent for biochemical and structural biology studies investigating protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	(S)-Fmoc-2-Amino-5-[(N'-Pbf-N''-Boc-Amino)-Guanidino]-Pentanoic Acid
CAS No.	1060769-54-1
Molecular Formula	C₃₇H₅₃N₅O₉S
Molecular Weight	743.91 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; Fmoc-NG-Pbf-NG'-Boc-L-arginine; Fmoc-L-arginine(Pbf)-OH; Nα-Fmoc-Nω-(NG-Pbf-NG'-Boc)-L-arginine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)((tert-butoxycarbonyl)amino)amino)pentanoic acid; Fmoc-Arg(Pbf,Boc)-OH; Boc-Pbf-Arg(Fmoc)-OH
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-2-Amino-5-[(N'-Pbf-N''-Boc-Amino)-Guanidino]-Pentanoic Acid is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive peptide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -14.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.