Description

Fmoc-Arg(T-Bu,Pbf)-Oh CAS NO 1060769-44-9 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). It serves as a critical building block for the controlled and efficient incorporation of arginine into complex peptide sequences, ensuring high coupling yields and minimizing side reactions. This reagent is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary building block for the sequential assembly of peptides containing arginine residues.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates, including hormones, antimicrobial peptides, and targeted therapeutics.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Intermediate for creating peptide-protein or peptide-small molecule conjugates for drug delivery and diagnostics.
• Academic Research: Fundamental tool for studying protein structure-function relationships, enzyme substrates, and signal transduction pathways.
• Custom Peptide Service Providers: A key raw material for commercial-scale production of custom peptides for clients worldwide.

Basic Information

Product Name	Fmoc-Arg(T-Bu,Pbf)-Oh
CAS No.	1060769-44-9
Molecular Formula	C36H52N4O7S
Molecular Weight	684.89 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-L-arginine(Pbf)-OH; Fmoc-Arg(T-Bu,Pbf)-OH; N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-Arg(Pbf)-OH (side-chain protected); Fmoc-Arginine(Pbf)-OH; Fmoc-Arg(Pbf)-OH (T-Bu ester)
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(T-Bu,Pbf)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications requiring GMP-grade and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.