Description

Fmoc-Arg(C-Pr,Pbf)-Oh CAS NO 1060769-41-6 is a protected arginine derivative, specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, sequence-specific peptides, as it provides orthogonal protection for the guanidino group, preventing side reactions and ensuring synthetic fidelity. It is an essential building block for the pharmaceutical, biotechnology, and academic research sectors engaged in the development of therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise assembly of complex peptide chains.
• Therapeutic Peptide Development: Used in the research and GMP-scale production of peptide-based drugs targeting metabolic disorders, oncology, and cardiovascular diseases.
• Bioconjugation and Labeling: Serves as a precursor for introducing arginine residues with specific functional handles for protein-peptide conjugation or fluorescent labeling.
• Antibiotic and Antimicrobial Peptide Research: Integral for synthesizing cationic peptides where the arginine side chain is crucial for biological activity.
• Peptide Library Construction: Employed in combinatorial chemistry for generating diverse peptide libraries used in high-throughput screening for drug discovery.
• Academic and Industrial R&D: A fundamental reagent in laboratories focused on peptide chemistry, structural biology, and medicinal chemistry.

Basic Information

Product Name	Fmoc-Arg(C-Pr,Pbf)-Oh
CAS No.	1060769-41-6
Molecular Formula	C₃₄H₄₇N₅O₇S
Molecular Weight	669.84 g/mol
Synonyms	Fmoc-Arg(Pbf)-OH; N-α-Fmoc-N-ω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Fmoc-L-arginine(Pbf)-OH; Fmoc-Arg(Pbf)-OH (Pbf protected); Fmoc-Arg(Pbf)-OH (C-Pr, Pbf); N-α-(9-Fluorenylmethoxycarbonyl)-N-ω-(Pbf)-L-arginine; Fmoc-Arg(Pbf)-OH (Side chain protected); Fmoc-Arg(Pbf)-OH (for SPPS)
EINECS	Contact for details

Quality Control

Our Fmoc-Arg(C-Pr,Pbf)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 98.5% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity, and related substances. We adhere to industry best practices suitable for research and development applications, with capabilities to meet more stringent standards for advanced pharmaceutical use upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.5%
Specific Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.