Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-[(3-Fluorophenyl)Sulfonyl]-1-Piperazinyl]-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel fluoroquinolone antibiotics, offering a key building block for research and development in antimicrobial therapies. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers targeting the active pharmaceutical ingredient (API) sector.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: Serves as a core structural component in the synthesis of next-generation antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in scaled-up manufacturing processes for producing bulk drug substances.
• Contract Manufacturing & Custom Synthesis: Supplied to CROs and CMOs for client-specific projects requiring high-purity, complex intermediates.
• Reference Standard: Can be utilized as an analytical standard for quality control and regulatory submissions.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-[(3-Fluorophenyl)Sulfonyl]-1-Piperazinyl]-1,4-Dihydro-4-Oxo-
CAS No.	1057934-96-9
Molecular Formula	C23H21F2N3O4S
Molecular Weight	473.49 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-[4-[(3-fluorophenyl)sulfonyl]-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-7-(4-(3-fluorophenylsulfonyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK-2140944 Intermediate; GSK-2140944 Precursor; Besifloxacin Intermediate; Besifloxacin Related Compound; 3-Quinolinecarboxylic acid derivative; Fluoroquinolone Intermediate B
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.