Description

3-Quinolinecarboxylic Acid, 7-[4-[(3-Cyanophenyl)Sulfonyl]-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- CAS NO 1057870-85-5 is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance due to its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the quinolone and fluoroquinolone antibiotic classes. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of next-generation antimicrobial agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel quinolone and fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs targeting DNA gyrase and topoisomerase IV inhibitors.
• Process Chemistry Development: Serves as a key starting material (KSM) or advanced intermediate in scalable API synthesis routes.
• Contract Manufacturing: Supplied to CMOs for the cGMP production of investigational new drugs (INDs) and new drug applications (NDAs).
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) in antibacterial compounds.
• Reference Standard: High-purity grades are suitable for use as analytical reference standards in quality control laboratories.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-[(3-Cyanophenyl)Sulfonyl]-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1057870-85-5
Molecular Formula	C24H22FN5O4S
Molecular Weight	495.53 g/mol
Synonyms	7-[4-[(3-Cyanophenyl)sulfonyl]-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-7-[4-[(3-cyanophenyl)sulfonyl]-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; 1057870-85-5; UNII-9J8F6C8Z4U; 9J8F6C8Z4U; A-143420; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-7-[4-[(3-cyanophenyl)sulfonyl]-1-piperazinyl]-4-oxo-; 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[(3-cyanophenyl)sulfonyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. The product undergoes rigorous analytical testing, including HPLC purity analysis, residual solvent screening, and structural confirmation (NMR, MS). A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each batch to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed under an inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.