Description

(1R)-6-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine is a chiral amine building block of significant interest in advanced pharmaceutical research and development. Its value lies in its role as a key synthetic intermediate for creating novel, optically active drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas. This high-purity intermediate is essential for medicinal chemists and process development scientists in pharmaceutical and biotechnology companies seeking to develop enantiomerically pure compounds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the discovery and optimization of drug candidates targeting specific biological pathways.
• Asymmetric Synthesis: Serves as a chiral precursor or auxiliary in stereoselective chemical transformations.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential drug substances.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(1R)-6-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine
CAS No.	1057246-78-2
Molecular Formula	C10H12FN
Molecular Weight	165.21 g/mol
Synonyms	(1R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine; (1R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-ylamine; (1R)-6-Fluoro-1,2,3,4-tetrahydro-1-naphthalenamine; (R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine; 1-Naphthalenamine, 6-fluoro-1,2,3,4-tetrahydro-, (1R)-; 6-Fluoro-(1R)-1,2,3,4-tetrahydronaphthalen-1-amine
EINECS	Contact for details

Quality Control

Our (1R)-6-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support development with custom synthesis and scale-up services to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.