Description

tert-Butyl 4-Chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of complex heterocyclic molecules, enabling the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers focused on oncology, kinase inhibitors, and other targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other small-molecule drug candidates.
• Chemical Synthesis Building Block: Used in medicinal chemistry for constructing complex pyridopyrimidine scaffolds, a privileged structure in drug discovery.
• Research & Development (R&D): Essential for academic and industrial research exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for active pharmaceutical ingredient (API) manufacturing.
• Contract Manufacturing (CMO/CDMO): Supplied to organizations specializing in custom synthesis and the production of non-commercial quantities for clinical trials.

Basic Information

Product Name	tert-Butyl 4-Chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
CAS No.	1056934-87-2
Molecular Formula	C12H14ClN3O2
Molecular Weight	267.71 g/mol
Synonyms	tert-Butyl 4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate; 6-(tert-Butoxycarbonyl)-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 4-Chloro-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 1056934-87-2; tert-Butyl 4-chloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate; 4-Chloro-6-Boc-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 4-Chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.