Description

Cyclo(-Arg-Ala-Asp-D-Phe-Cys) is a synthetic, cyclic pentapeptide featuring a disulfide bridge, designed as a potent and selective integrin antagonist. This compound is of significant value in biochemical and pharmaceutical research for its role in modulating cell adhesion and signaling pathways. It is primarily needed by researchers and developers in the fields of oncology, cardiovascular disease, and regenerative medicine for use in target validation, drug discovery, and as a biochemical tool.

Application

• Biochemical Research: Used as a selective high-affinity ligand to study αvβ3, αvβ5, and α5β1 integrin receptor functions in cell adhesion, migration, and angiogenesis assays.
• Pharmaceutical Development: Serves as a reference standard, lead compound, or pharmacophore model in the discovery of novel anti-angiogenic and anti-metastatic therapeutics.
• Cancer Research: Applied in in vitro and in vivo studies to investigate tumor progression, metastasis, and to evaluate potential therapeutic strategies targeting integrins.
• Diagnostic Probe Development: Utilized as a backbone for developing targeted imaging agents (e.g., for PET or fluorescence imaging) to visualize integrin expression in diseased tissues.
• Biomaterial Functionalization: Coated onto surfaces or scaffolds to create bioactive interfaces that control cell attachment and behavior in tissue engineering applications.

Basic Information

Product Name	Cyclo(-Arg-Ala-Asp-D-Phe-Cys)
CAS No.	1055991-02-0
Molecular Formula	C27H39N9O7S2
Molecular Weight	665.8 g/mol
Synonyms	c(RGDfC); Cyclo(Arg-Gly-Asp-D-Phe-Cys); Cyclo(RGDfC); Cilengitide intermediate; Cyclo(-Arg-Gly-Asp-D-Phe-Cys); cRGDfC peptide; Integrin αvβ3 antagonist (cyclic RGDfC); Cyclic RGDfC Pentapeptide
EINECS	Contact for details

Quality Control

Our Cyclo(-Arg-Ala-Asp-D-Phe-Cys) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure structural integrity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting research and development requiring high-purity, well-characterized biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.