Description

(1R)-7-Fluoro-1,2,3,4-Tetrahydronaphthylamine is a chiral, fluorinated amine derivative of 1,2,3,4-tetrahydronaphthalene, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of active pharmaceutical ingredients (APIs), where its specific stereochemistry and fluorine substitution are essential for biological activity. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel therapeutic agents, particularly in the central nervous system (CNS) and cardiovascular domains.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in neurological and psychiatric research.
• Asymmetric Synthesis: Used in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Fluorinated Compound Library: Serves as a valuable scaffold for generating libraries of fluorinated molecules in drug discovery programs.
• Agrochemical Development: Potential application as an intermediate in the synthesis of advanced, fluorinated agrochemicals.
• Material Science Precursor: Can be utilized in the development of specialty chemicals and advanced organic materials.

Basic Information

Product Name	(1R)-7-Fluoro-1,2,3,4-Tetrahydronaphthylamine
CAS No.	1055949-62-6
Molecular Formula	C10H12FN
Molecular Weight	165.21 g/mol
Synonyms	(1R)-7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine; (1R)-7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-ylamine; (1R)-7-Fluoro-1,2,3,4-tetrahydronaphthyl-1-amine; (R)-7-Fluoro-1,2,3,4-tetrahydronaphthylamine; (R)-7-Fluoro-1,2,3,4-tetrahydro-1-naphthylamine; 7-Fluoro-(1R)-1,2,3,4-tetrahydronaphthylamine; 1-Naphthalenamine, 7-fluoro-1,2,3,4-tetrahydro-, (1R)-
EINECS	Contact for details

Quality Control

Our (1R)-7-Fluoro-1,2,3,4-Tetrahydronaphthylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure compliance with the high-purity standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications for identity, purity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.