Description

3-Quinolinecarboxylic Acid, 7-[4-(5-Chloro-2-Methoxybenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of antibacterial and anti-infective pharmaceuticals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for synthesizing active pharmaceutical ingredients (APIs). The product, identified by CAS No. 1054130-53-8, is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthesis workflows.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel quinolone and fluoroquinolone-based antibacterial agents.
• Antibiotic Research: Used in medicinal chemistry for the development of new compounds targeting DNA gyrase and topoisomerase IV enzymes.
• Process Chemistry: Serves as a critical intermediate in scale-up and optimization studies for API manufacturing processes.
• Biochemical Research: Employed in academic and industrial labs to study structure-activity relationships (SAR) of complex heterocycles.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method development in API production.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-(5-Chloro-2-Methoxybenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054130-53-8
Molecular Formula	C25H23ClFN3O4
Molecular Weight	483.92 g/mol
Synonyms	7-[4-(5-Chloro-2-methoxybenzoyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-[4-(5-chloro-2-methoxybenzoyl)-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; GSK-2140944 Intermediate; Gepotidacin Intermediate; Antibacterial Quinolone Intermediate; 1054130-53-8; 7-(4-(5-Chloro-2-methoxybenzoyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, and residual solvents. We adhere to cGMP (current Good Manufacturing Practice) principles where applicable to support our global clientele in regulated markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.