Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[3-(2-Methylphenoxy)-1-Oxopropyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of novel fluoroquinolone antibiotics, offering a key building block for research and development in antimicrobial therapies. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences sector.

Application

• Key Intermediate in Fluoroquinolone Antibiotic Synthesis: Serves as a core structural component in the development of next-generation antibacterial agents.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions.
• Custom Synthesis: A starting material for the preparation of specialized derivatives and analogs for biological screening.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[3-(2-Methylphenoxy)-1-Oxopropyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1054130-07-2
Molecular Formula	C27H28FN3O5
Molecular Weight	493.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[3-(2-methylphenoxy)-1-oxopropyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(3-(2-Methylphenoxy)propionyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Garenoxacin Intermediate; Garenoxacin Carboxylic Acid Derivative; 1-Cyclopropyl-6-fluoro-7-(4-(3-(o-methylphenoxy)propionyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; AM-1155 Intermediate; OPC-17116 Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.