Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[3-(3-Methylphenoxy)-1-Oxopropyl]-1-Piperazinyl]-4-Oxo- is a high-purity advanced pharmaceutical intermediate (API intermediate) with a complex heterocyclic structure. This compound is critical for the research and development of novel antibacterial agents, particularly within the fluoroquinolone class. It is primarily utilized by pharmaceutical R&D laboratories and manufacturing facilities engaged in the synthesis of next-generation antibiotics. Our supply is characterized by stringent quality control to ensure batch-to-batch consistency for critical synthesis pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under cGMP conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API production.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis for clinical trial material production.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[3-(3-Methylphenoxy)-1-Oxopropyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1054129-99-5
Molecular Formula	C27H28FN3O5
Molecular Weight	493.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[3-(3-methylphenoxy)-1-oxopropyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-[3-(3-Methylphenoxy)propionyl]piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Garenoxacin Intermediate; Garenoxacin Carboxylic Acid Derivative; AM-1155 Intermediate; T-3811 Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(3-(3-methylphenoxy)propionyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring it meets the exacting standards required for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development needs with material produced under quality guidelines suitable for use in non-GMP and GMP-regulated synthesis upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.