Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(3,4-Dimethylbenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic building block in the development of novel therapeutic agents, particularly within the antibacterial class. It is primarily sought after by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of next-generation antibacterial agents, particularly fluoroquinolone derivatives.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel antibiotic candidates targeting resistant bacterial strains.
• Chemical Synthesis Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Contract Manufacturing: Supplied to CDMOs for scale-up and commercial production under current Good Manufacturing Practice (cGMP) conditions.
• Reference Standard: High-purity grades are utilized as analytical reference standards for quality control and regulatory submissions.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(3,4-Dimethylbenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054129-51-9
Molecular Formula	C26H26FN3O3
Molecular Weight	447.51 g/mol
Synonyms	1-Cyclopropyl-7-[4-(3,4-dimethylbenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771; WCK-771; WCK 771 Intermediate; Levonadifloxacin Alalevonadifloxacin Intermediate; Levonadifloxacin Impurity; (1-Cyclopropyl-6-fluoro-4-oxo-7-(4-(3,4-dimethylbenzoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic Acid)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical applications. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting customer specifications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. We support development and commercial projects with quality standards aligned with ICH guidelines and can supply material manufactured under cGMP conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.