Description

3-Quinolinecarboxylic Acid, 7-[4-(4-Cyanobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex molecular structure, featuring a quinoline core with piperazine and cyclopropyl substituents, makes it a critical building block in modern synthetic chemistry. This compound is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within the antibacterial and quinolone-based therapeutic classes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of novel antibacterial agents, especially advanced fluoroquinolone antibiotics.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new drug candidates targeting bacterial infections.
• Process Chemistry: Serves as a critical intermediate in scaling up and optimizing synthetic routes for API manufacturing under Good Manufacturing Practice (GMP) conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial drug substances.
• Chemical Synthesis: Utilized in academic and industrial laboratories for exploring new organic reactions and constructing complex heterocyclic systems.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[4-(4-Cyanobenzoyl)-1-Piperazinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054110-85-8
Molecular Formula	C25H21FN4O3
Molecular Weight	444.46 g/mol
Synonyms	7-[4-(4-Cyanobenzoyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-[4-(4-cyanobenzoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Intermediate for Antibacterial Agents; Quinolone Derivative Intermediate; 1054110-85-8; CAS 1054110-85-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development from laboratory to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.