Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Methyl-1-Oxo-2-Phenylpropyl)-1-Piperazinyl]-4-Oxo- is a high-purity advanced pharmaceutical intermediate with the CAS number 1054048-00-8. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), valued for its precise molecular structure and reactivity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex, high-value active pharmaceutical ingredients (APIs).
• Antibacterial Research: Serves as a core structural component in the research and development of next-generation quinolone and fluoroquinolone antibacterial agents.
• Organic Synthesis: Used in advanced organic chemistry for constructing complex heterocyclic frameworks in medicinal chemistry programs.
• Process Development: Employed in scale-up and process optimization studies within pharmaceutical R&D and manufacturing.
• Reference Standard: Utilized as an analytical reference standard for quality control and method validation in API production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Methyl-1-Oxo-2-Phenylpropyl)-1-Piperazinyl]-4-Oxo-
CAS No.	1054048-00-8
Molecular Formula	C27H28FN3O4
Molecular Weight	477.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(2-methyl-1-oxo-2-phenylpropyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(α-Methyl-α-phenylglycyl)-1-piperazinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; Intermediate for Garenoxacin; Garenoxacin intermediate; T-3811 intermediate; OPC-17116 intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(2-methyl-1-oxo-2-phenylpropyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.