Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[(5-Ethyl-4-Methyl-2-Thienyl)Carbonyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. Pharmaceutical R&D teams and fine chemical manufacturers need this material for developing next-generation antibacterial agents and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel fluoroquinolone antibiotics and other therapeutic molecules.
• Antibacterial Drug Development: Used in the synthesis of compounds targeting DNA gyrase and topoisomerase IV enzymes in pathogenic bacteria.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring high-purity, complex heterocyclic carboxylic acid derivatives.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of clinical trial materials and commercial APIs.
• Biochemical Research: Potential use as a tool compound for studying bacterial resistance mechanisms and enzyme inhibition.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[(5-Ethyl-4-Methyl-2-Thienyl)Carbonyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054011-39-0
Molecular Formula	C24H25FN3O4S
Molecular Weight	470.54 g/mol
Synonyms	1-Cyclopropyl-7-[4-[(5-ethyl-4-methyl-2-thienyl)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-[(5-ethyl-4-methyl-2-thienyl)carbonyl]-1-piperazinyl)-3-quinolinecarboxylic Acid; WCK 771 Intermediate; NXL 101 Intermediate; Advanced Fluoroquinolone Intermediate; (1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid) derivative; Contact for additional trade names and research codes.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities to meet the exacting standards of pharmaceutical development. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to support regulatory filings (e.g., DMF, CMC sections). We adhere to ICH Q7 guidelines and can supply material suitable for use in GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.