Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(2,6-Dimethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex molecular structure makes it a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. This compound is essential for pharmaceutical R&D laboratories and manufacturers focused on developing next-generation antibacterial agents and exploring new therapeutic applications.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of advanced fluoroquinolone antibiotics.
• Antibacterial Drug Development: Serves as a core scaffold for research into new antibacterial agents with potentially improved efficacy and spectrum of activity.
• Chemical Synthesis & Process R&D: Used in route scouting, process optimization, and scale-up studies for API production.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Biochemical Research: Utilized in studies investigating bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.
• Custom Synthesis: A starting material for the custom synthesis of specialized analogs for proprietary drug discovery programs.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(2,6-Dimethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054011-23-2
Molecular Formula	C27H27FN3O4
Molecular Weight	476.52 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-(4-[(2,6-dimethylphenoxy)acetyl]piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; 1-Cyclopropyl-7-[4-[2-(2,6-Dimethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid; Levonadifloxacin Intermediate; (S)-(-)-9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic Acid L-arginine salt methoxy intermediate (related); Benzo[i,j]quinolizine-2-carboxylic acid derivative; Antibacterial Agent Intermediate.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical R&D and scale-up. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for impurity profiling and can supply material that meets the stringent requirements for use in GMP-compliant manufacturing processes upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.