Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(3,4-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity advanced pharmaceutical intermediate (API intermediate) with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of antibacterial fluoroquinolones. It is primarily sought by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in the synthesis of next-generation active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluoroquinolone antibiotic candidates.
• Antibacterial Drug Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antibacterial agents.
• Process Development: Serves as a critical intermediate for scaling up API manufacturing processes under cGMP conditions.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Custom Synthesis: Starting material for the custom synthesis of specialized chemical entities for biological screening and testing.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(3,4-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1054009-58-3
Molecular Formula	C26H26FN3O5
Molecular Weight	479.50 g/mol
Synonyms	1-Cyclopropyl-7-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic Acid; 1-Cyclopropyl-6-fluoro-7-(4-(3,4-dimethoxybenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK-2140944 Intermediate; Gepotidacin Intermediate; Antibacterial Intermediate 1054009-58-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.