Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[(3-Methyl-2-Thienyl)Carbonyl]-1-Piperazinyl]-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates, particularly in antibiotic and antimicrobial research.
• Antibacterial Agent Research: Serves as a core structural component for developing new fluoroquinolone-class antibacterial compounds.
• Chemical Synthesis Building Block: Used in organic synthesis for constructing complex molecules with quinoline and piperazine moieties.
• Process Development & Scale-Up: Employed in process chemistry for optimizing synthetic routes from laboratory to pilot and commercial scale.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and drug development services.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-[(3-Methyl-2-Thienyl)Carbonyl]-1-Piperazinyl]-4-Oxo-
CAS No.	1054009-26-5
Molecular Formula	C22H21FN3O3S
Molecular Weight	426.48 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-[(3-methyl-2-thienyl)carbonyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid; 7-[4-(3-Methylthiophene-2-carbonyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-7-[4-(3-methylthiophene-2-carbonyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; GSK-2140944 Intermediate; GSK2140944 Intermediate; GSK 2140944 Intermediate; Besifloxacin Intermediate; BOL-303224-A Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.