Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(3-Ethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone-class antibacterial agents, valued for its complex heterocyclic structure. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) engaged in the synthesis of next-generation antibiotics and antimicrobial compounds.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel fluoroquinolone antibiotics targeting resistant bacterial strains.
• Antimicrobial Research: Used in medicinal chemistry programs to develop new antibacterial agents with improved potency and spectrum of activity.
• Chemical Synthesis: Serves as a versatile scaffold for the preparation of structurally complex quinoline derivatives for biological screening.
• Process Development: Employed in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) in antibacterial drug design.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-[2-(3-Ethylphenoxy)Acetyl]-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053951-56-6
Molecular Formula	C26H26FN3O4
Molecular Weight	463.50 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-[4-[2-(3-ethylphenoxy)acetyl]piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-7-[4-[2-(3-ethylphenoxy)acetyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; GSK2140944 Intermediate; GSK'044 Intermediate; 1053951-56-6; Besifloxacin related compound; Advanced Fluoroquinolone Intermediate.
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the rigorous standards required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (on dried basis)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.