Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,4-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex molecular structure, featuring a quinolinecarboxylic acid core with cyclopropyl, fluoro, and piperazinyl substituents, makes it a critical building block in modern synthetic chemistry. This compound is primarily sought after by R&D and production teams in the pharmaceutical industry for the development and synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antibiotic and antibacterial agents, particularly fluoroquinolone derivatives.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for research into new therapeutic compounds targeting bacterial infections.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of drug candidates.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for complex molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical sector.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2,4-Dimethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053950-65-4
Molecular Formula	C26H25FN3O5
Molecular Weight	478.50 g/mol
Synonyms	1-Cyclopropyl-7-[4-(2,4-dimethoxybenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2,4-dimethoxybenzoyl)-1-piperazinyl)-3-quinolinecarboxylic Acid; WCK 771 Intermediate; Advanced Fluoroquinolone Intermediate; 1-Cyclopropyl-6-fluoro-7-(4-(2,4-dimethoxybenzoyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability. The material is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.