Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2-Ethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel fluoroquinolone antibiotics, valued for its complex heterocyclic structure. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis specialists for the production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel fluoroquinolone-class antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new antibacterial drug candidates.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize antibacterial potency and spectrum.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of specialized, high-value organic molecules.
• Biochemical Research: Potential use as a tool compound for studying bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[4-(2-Ethoxybenzoyl)-1-Piperazinyl]-6-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	1053950-43-8
Molecular Formula	C26H26FN3O4
Molecular Weight	463.50 g/mol
Synonyms	1-Cyclopropyl-7-[4-(2-ethoxybenzoyl)piperazin-1-yl]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WCK 771 Intermediate; Levonadifloxacin Intermediate; 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2-ethoxybenzoyl)-1-piperazinyl)-3-quinolinecarboxylic Acid; Benzanilide, 2-ethoxy-4'-(7-carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolyl)-1-piperazinyl-; Levonadifloxacin (Benzoyl) Intermediate; (1-Cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinolin-3-yl)-[4-(2-ethoxybenzoyl)piperazin-1-yl]methanone (tautomeric form).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical applications. Quality is verified through comprehensive analytical methods including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor specifications to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.